INTRAOCULAR DICLOFENAC AND FLURBIPROFEN CONCENTRATIONS IN HUMAN AQUEOUS-HUMOR FOLLOWING TOPICAL APPLICATION

被引：37

作者：

ELLIS, PP

PFOFF, DS

BLOEDOW, DC

RIEGEL, M

机构：

[1] Department of Ophthalmology, University of Colorado School of Medicine, Denver, Colorado

来源：

JOURNAL OF OCULAR PHARMACOLOGY | 1994年 / 10卷 / 04期

关键词：

D O I：

10.1089/jop.1994.10.677

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Flurbiprofen Na and diclofenac Na, two ocular antiinflammatory agents, were investigated to determine the aqueous humor concentrations in the human eye following topical application. One hundred sixty-five patients undergoing cataract surgery received a single drop of either diclofenac Na or flurbiprofen Na at selected times prior to the surgical procedure. Aqueous humor samples were aspirated at the beginning of surgery and a sensitive high-performance liquid chromatographic assay was used to determine the concentration of the antiinflammatory agent in the ocular fluid. Samples were obtained between 10 min and 24 hrs after a single instillation of the drug onto the cornea. The highest average concentration of diclofenac was 82 ng/ml at 2.4 hrs after instillation; concentrations remained above 20 ng/ml for over 4 hrs. Thereafter, between 3 and 16 ng/ml diclofenac could be assayed through 24 hrs. The highest average concentration of flurbiprofen, 60 ng/ml, was found at 2.0 hrs. The last detectable flurbiprofen concentration was measured at 7.25 hrs after instillation.

引用

页码：677 / 682

页数：6

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