SYNTHESIS OF ALL THE STEREOISOMERS OF STATINE (4-AMINO-3-HYDROXY-6-METHYLHEPTANOIC ACID) - INHIBITION OF PEPSIN ACTIVITY BY N-CARBOBENZOXY-L-VALYL-L-VALYL-STATINE DERIVED FROM THE 4 STEREOISOMERS

被引：28

作者：

LIU, WS ^{[1
]}

SMITH, SC ^{[1
]}

GLOVER, GI ^{[1
]}

机构：

[1] TEXAS A&M UNIV,DEPT CHEM,COLLEGE STN,TX 77843

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1979年 / 22卷 / 05期

关键词：

D O I：

10.1021/jm00191a023

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Synthesis of all four stereoisomers of the novel amino acid statine, 4-amino-3-hydroxy-6-methylheptanoic acid, found in pepstatin, a potent acid protease inhibitor, has been accomplished. Carbobenzoxy-L-valyl-L-valyl-statine tripeptides derived from all four stereoisomers have been prepared and their effect on pepsin activity is compared to that of pepstatin. © 1979, American Chemical Society. All rights reserved.

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页码：577 / 579

页数：3

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