PROTEASES ARE MITOGENIC TO MESENCHYME INVIVO - STUDY USING THE CHICK-EMBRYO CHORIOALLANTOIC MEMBRANE

被引：7

作者：

GRUMM, FG ^{[1
]}

ARMSTRONG, PB ^{[1
]}

机构：

[1] UNIV CALIF DAVIS, DEPT ZOOL, DAVIS, CA 95616 USA

来源：

EXPERIMENTAL CELL RESEARCH | 1979年 / 119卷 / 02期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/0014-4827(79)90359-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The chorioallantoic membrane (CAM) of the 9 and 10 day chick embryo has been used as a system to investigate the control of growth of mesenchymal tissue in vivo. The mesenchyme (but not the chorionic epithelium or allantoic epithelium) responded to the mitogenic stimuli of trypsin, activated macrophages and the secreted products of activated macrophages. The response to trypsin mimics the response of chick embryo fibroblasts in vitro. Under the conditions used, the increased labeling index was observed in CAM mesenchyme by 6 h (the shortest time assayed) and remained at this level for at least 24 h. This system could be used to evaluate the mitogenicity in vivo of other substances known to be mitogenic to fibroblasts in vitro. © 1979.

引用

页码：317 / 326

页数：10

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