CHANGES IN ENZYME-ACTIVITIES IN SKIN FIBROBLASTS DERIVED FROM PERSONS OF VARIOUS AGES

被引：28

作者：

SHINDO, Y

AKIYAMA, J

YAMAZAKI, Y

SAITO, K

TAKASE, Y

机构：

[1] Department of Dermatology, Shinshu University School of Medicine, Matsumoto, 390

来源：

EXPERIMENTAL GERONTOLOGY | 1991年 / 26卷 / 01期

关键词：

CATALASE; SUPEROXIDE DISMUTASE; GLUTATHIONE PEROXIDASE; HUMAN SKIN FIBROBLAST;

D O I：

10.1016/0531-5565(91)90059-U

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

We examined antioxidant enzyme activities (catalase, glutathione peroxidase, and superoxide dismutase) in cultured skin fibroblasts (passage number 2-3) derived from 30 persons of various ages. With increasing ages, catalase activity decreased, glutathione peroxidase activity increased slightly, and superoxide dismutase activity was unchanged. After UVA irradiation (4.8 joule/cm2) of the fibroblasts, only catalase activity decreased by 70%. This suggests that catalase may play an important role in the aging of human skin fibroblasts.

引用

页码：29 / 35

页数：7

共 19 条

[1]

Abei H. E., 1974, METHOD ENZYMATIC ANA, P673

[2]

Bergmeyer HU, 1974, METHOD ENZYMAT AN, V1, P465

[3] GLUTATHIONE PEROXIDASE - PRIMARY AGENT FOR ELIMINATION OF HYDROGEN PEROXIDE IN ERYTHROCYTES [J].