PROLINE SPECIFIC PEPTIDASES AND THEIR SPECIFIC INHIBITORS

被引：9

作者：

YOSHIMOTO, T

机构：

来源：

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN | 1991年 / 111卷 / 07期

关键词：

PROLINE SPECIFIC PEPTIDASE; PROLINE; PROLYL ENDOPEPTIDASE; PROLINE IMINOPEPTIDASE; AMINOPEPTIDASE-P; INHIBITOR; CLONING; NUCLEOTIDE SEQUENCE;

D O I：

10.1248/yakushi1947.111.7_345

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Several proline specific peptidases were newly isolated from mammalian organs, plants and microorganisms, and their enzymatic properties characterized. The genes of prolyl endopeptidase, aminopeptidase P and proline iminopeptidase from some microorganisms were cloned and their nucleotide sequences determined. By high expression of these genes in Escherichia coli, the enzymes became possible to be used for the industrial application as well as its basic research. Novel inhibitors specific for the prolyl endopeptidase and dipeptidyl aminopeptidase IV were synthesized and some inhibitors for prolyl endopeptidase found to show an anti-amnesic effect.

引用

页码：345 / 358

页数：14

共 45 条

[1] DEFICIENCY OF KALLIKREIN-LIKE ENZYME-ACTIVITIES IN CEREBRAL TISSUE OF PATIENTS WITH ALZHEIMERS-DISEASE [J].