FASTER QUANTITATIVE-EVALUATION OF HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY ULTRAVIOLET DIODE-ARRAY DATA BY MULTICOMPONENT ANALYSIS

被引:18
作者
EXCOFFIER, JL
JOSEPH, M
ROBINSON, JJ
SHEEHAN, TL
机构
[1] Varian Chromatography Systems, Walnut Creek, CA 94598
来源
JOURNAL OF CHROMATOGRAPHY | 1993年 / 631卷 / 1-2期
关键词
D O I
10.1016/0021-9673(93)80503-Z
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Multicomponent analysis is a proven technique to analyze mixes of known UV-absorbing compounds in unknown amounts. While it is routinely used in spectrophotometers, its application to chromatography has so far been limited. This paper discusses an approach to obtain fast and accurate quantitation of unresolved chromatographic data, while providing for the detection of unexpected impurities. The applications of the technique to different conditions of chromatographic resolution are discussed, along with its potential for increasing sample throughput.
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页码:15 / 21
页数:7
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