A MEXILETINE INTOXICATION

被引：10

作者：

KEMPTON, J

MANOUKIAN, A

LEVINE, B

SMIALEK, J

机构：

[1] Office of the Chief Medical Examiner, State of Maryland, Baltimore, MD, 21201

来源：

JOURNAL OF ANALYTICAL TOXICOLOGY | 1994年 / 18卷 / 06期

关键词：

D O I：

10.1093/jat/18.6.346

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A case is presented of a 26-year-old white male with a history of depression and previous suicide attempts. No anatomic cause of death was determined at the autopsy. Comprehensive toxicological analysis of the blood and urine specimens identified mexiletine, a class 1B antiarrhythmic drug. Mexiletine was detected by gas chromatography and confirmed by gas chromatography-mass spectrometry. Quantitations were as follows: heart blood, 38 mg/L; subclavian blood, 14 mg/L; urine, 370 mg/L; liver, 190 mg/kg; kidney, 170 mg/kg; vitreous humor, 17 mg/L; and bile, 440 mg/L. The medical examiner ruled that the cause of death was mexiletine intoxication and the manner of death was suicide. © 1994, Oxford University Press.

引用

页码：346 / 347

页数：2