LACK OF RH C/E EXPRESSION IN THE RHESUS D-- PHENOTYPE IS THE RESULT OF A GENE DELETION

被引：28

作者：

BLUNT, T ^{[1
]}

STEERS, F ^{[1
]}

DANIELS, G ^{[1
]}

CARRITT, B ^{[1
]}

机构：

[1] UNIV LONDON UNIV COLL,MRC,BLOOD GRP UNIT,GALTON LAB,LONDON NW1 2HE,ENGLAND

来源：

ANNALS OF HUMAN GENETICS | 1994年 / 58卷

关键词：

D O I：

10.1111/j.1469-1809.1994.tb00722.x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We have investigated the arrangement of genes in the rare Rh (Rhesus) partial null condition D--. Southern blot and PCR studies under conditions which distinguish the highly homologous RH D and RH C/E genes show that in an Icelandic family with the D-- haplotype at least 85 % of the RH C/E gene is deleted. This finding is in contrast to one other published case of this phenotype, where intact RH D and C/E genes were found, and also to the full amorph Rh-null phenotype, where an intact RH C/E gene was found, accompanied by the deletion of the RH D gene typical of Rh D-negative individuals.

引用

页码：19 / 24

页数：6

共 18 条

[1]

ARCE MA, 1993, BLOOD, V82, P651

[2] CDNA CLONING OF A 30-KDA ERYTHROCYTE-MEMBRANE PROTEIN ASSOCIATED WITH RH (RHESUS)-BLOOD-GROUP-ANTIGEN EXPRESSION [J].

AVENT, ND ;

RIDGWELL, K ;

TANNER, MJA ;

ANSTEE, DJ .

BIOCHEMICAL JOURNAL, 1990, 271 (03) :821-825

[3]

CAPRITT B, 1986, AM J HUM GENET, V38, P428

[4]

CAPRITT B, 1993, ANN HUM GENET, V57, P273

[5] STRUCTURE AND EXPRESSION OF THE RH LOCUS IN THE RH-DEFICIENCY SYNDROME [J].

CHERIFZAHAR, B ;

RAYNAL, V ;

LEVANKIM, C ;

DAMBROSIO, AM ;

BAILLY, P ;

CARTRON, JP ;

COLIN, Y .

BLOOD, 1993, 82 (02) :656-662

[6]

CHERIFZAHAR B, 1990, P NATL ACAD SCI USA, V87, P8243

[7]

COLIN Y, 1991, BLOOD, V78, P2747

[8]

CONNOR J, 1992, J BIOL CHEM, V267, P26050

[9] RAPID ISOLATION OF HUMAN CHROMOSOME-SPECIFIC DNA PROBES FROM A SOMATIC-CELL HYBRID [J].

COTTER, FE ;

HAMPTON, GM ;

NASIPURI, S ;

BODMER, WF ;

YOUNG, BD .

GENOMICS, 1990, 7 (02) :257-263

[10]

KAJII E, 1993, HUM GENET, V91, P157

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