SYNTHESIS OF 4-EPI-2-DEOXY-2-H-EQ-N-ACETYLNEURAMINIC ACID AND 2,4-DIDEOXY-2-H-EQ-N-ACETYLNEURAMINIC ACID

被引：4

作者：

BANDGAR, BP ^{[1
]}

ZBIRAL, E ^{[1
]}

机构：

[1] UNIV VIENNA,INST ORGAN CHEM,A-1090 VIENNA,AUSTRIA

来源：

CARBOHYDRATE RESEARCH | 1995年 / 270卷 / 02期

关键词：

4-EPI-2-DEOXY-2-H-EQ-N-ACETYLNEURAMINIC ACID 2,4-DIDEOXY-2-H-EQ-N-ACETYLNEURAMINIC ACID;

D O I：

10.1016/0008-6215(95)00013-J

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have continued our work to develop novel analogues of sialic acid [1-4] that may specifically modulate the interaction between endogenous sialic acid and influenza virus haemagglutinin [3,5,6]. Functional groups of sialic acid that have been implicated for this virus-host recongnition are the glycerol side chain, N-acetyl group and the axially oriented carboxylic acid function [3]. In this report we describe the synthesis of two analogues, namely, 4-epi-2-deoxy-2-H-eq-N-acetylneuraminic acid (4-epi-2-d-2-H-eq-Neu5Ac) and 2,4-dideoxy-2-H-eq-N-acetylneuraminic acid (2,4-d(2)-2-H-eq-Neu5Ac).

引用

页码：201 / 210

页数：10

共 15 条

[1]

ANAZAWA K, 1988, CHEM PHARM BULL, V36, P4976

[2] STRUCTURAL TRANSFORMATIONS OF N-ACETYLNEURAMINIC ACID .25. SYNTHESIS OF METHYL-2-ALPHA-GLYCOSIDES OF 4-EPI-N-ACETYLNEURAMINIC, 7-EPI-N-ACETYLNEURAMINIC, 8-EPI-N-ACETYLNEURAMINIC, AND 7,8-BIS-EPI-N-ACETYLNEURAMINIC ACIDS [J].