SEVERE INTRACRANIAL HEMORRHAGE IN A NEWBORN-INFANT WITH TRANSPLACENTAL TRANSFER OF AN ACQUIRED FACTOR VIII-C INHIBITOR

We describe a woman in whom inhibitors to factor VIII:C developed in her first pregnancy, The neonate had a factor VIII:C level of 1% and an inhibitor titer of 5.2 Bethesda units, After an uneventful vaginal delivery, the boy had an intracranial hemorrhage at 5 days of age, To our knowledge, this is the first report of a bleeding complication in a newborn infant with transplacental transfer of an acquired factor VIII:C inhibitor.