SACCHARIN-INDUCED SISTER CHROMATID EXCHANGES IN CHINESE-HAMSTER AND HUMAN CELLS

被引：63

作者：

WOLFF, S ^{[1
]}

RODIN, B ^{[1
]}

机构：

[1] UNIV CALIF SAN FRANCISCO,DEPT ANAT,SAN FRANCISCO,CA 94143

来源：

SCIENCE | 1978年 / 200卷 / 4341期

关键词：

D O I：

10.1126/science.644315

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Since the induction of sister chromatid exchanges in cultured cells has been shown to be the most sensitive mammalian system to detect the effects of mutagenic carcinogens, Chinese hamster ovary cells and human lymphocytes were exposed to the sodium saccharin found to induce bladder cancer in rats. Both that saccharin and a highly purified extract of it increased the yield of sister chromatid exchanges in both types of cells. The results, which were repeatable and statistically highly significant, indicated that the weak carcinogen, saccharin, is also mutagenic in the sense that it induces cytogenetic changes. Copyright © 1978 AAAS.

引用

页码：543 / 545

页数：3

共 14 条

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