9-BETA-D-ARABINOFURANOSYL-8-NORMAL-BUTYLAMINOADENINE, A C-8 SUBSTITUTED NUCLEOSIDE IN THE ANTI CONFORMATION - CRYSTALLOGRAPHIC AND NMR-STUDIES

被引：20

作者：

NEIDLE, S ^{[1
]}

SANDERSON, MR ^{[1
]}

SUBBIAH, A ^{[1
]}

CHATTOPADHYAYA, JB ^{[1
]}

KURODA, R ^{[1
]}

REESE, CB ^{[1
]}

机构：

[1] UNIV LONDON KINGS COLL,DEPT CHEM,LONDON WC2R 2LS,ENGLAND

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1979年 / 565卷 / 02期

关键词：

9-β-d-Arabinofuranosyl-8-n-butylaminoadenine; NMR; Nucleoside conformation; X-ray crystallography;

D O I：

10.1016/0005-2787(79)90213-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The protein NMR spectrum of 9-β-d-arabinofuranosyl-8-n-butylaminoadenine shows an unusually low-field 5′-hydroxyl proton resonance, which has been interpreted in terms of an anti glycosidic conformation together with an 05′ ... N8 intramolecular hydrogen bond. Confirmatory evidence for this was obtained by an X-ray crystallographic study; in the crystal, the glycosidic angle ḩi is 52.7° and the sugar pucker is C3′ endo-C4′ exo. © 1979.

引用

页码：379 / 386

页数：8

共 17 条

[1] CONFORMATIONAL-ANALYSIS OF SUGAR RING IN NUCLEOSIDES AND NUCLEOTIDES - NEW DESCRIPTION USING CONCEPT OF PSEUDOROTATION
ALTONA, C
SUNDARALINGAM, M
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1972, 94 (23) : 8205 - +
[2] [Anonymous], 1968, ADV PHYS ORG CHEM
[3] PURINE NUCLEOSIDE UNEQUIVOCALLY CONSTRAINED IN SYN FORM - CRYSTAL-STRUCTURE AND CONFORMATION OF 8-(ALPHA-HYDROXYISOPROPYL)-ADENOSINE
BIRNBAUM, GI
SHUGAR, D
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1978, 517 (02) : 500 - 510
[4] CHATTOPADHYAYA JB, 1977, SYNTHESIS-STUTTGART, P725
[5] REACTION OF 8,2'-OMICRON-CYCLOADENOSINE WITH HYDRAZINE AND AMINES - CONVENIENT PREPARATIONS OF 9-BETA-D-ARABINOFURANOSYLADENINE AND ITS DERIVATIVES
CHATTOPADHYAYA, JB
REESE, CB
[J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1977, (12) : 414 - 415
[6] CRYSTAL-STRUCTURE OF ADENOSINE
LAI, TF
MARSH, RE
[J]. ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL CRYSTALLOGRAPHY AND CRYSTAL CHEMISTRY, 1972, B 28 (JUL15): : 1982 - &
[7] CRYSTAL-STRUCTURE OF AN ORTHORHOMBIC FORM OF ADENOSINE-5'-MONOPHOSPHATE
NEIDLE, S
KUHLBRANDT, W
ACHARI, A
[J]. ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE, 1976, 32 (JUN15): : 1850 - 1855
[8] NEIDLE S, 1978, NUCLEIC ACIDS RES, V5, P4417, DOI 10.1093/nar/5.11.4417
[9] PROHORILLE A, 1978, BIOCH BIOPHYS ACTA, V517, P511
[10] H-1 NUCLEAR MAGNETIC-RESONANCE SPECTROSCOPIC STUDY OF SOME N-METHYL AND N-ACYL DERIVATIVES OF GUANOSINE - STRUCTURE OF N,O(2'),O(3',,O(5')-TETRA-ACETYLGUANOSINE
REESE, CB
SAFFHILL, R
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1972, (23): : 2937 - 2940

← 1 2 →