DISTAL DENERVATING DISEASE - DEGENERATIVE NEUROPATHY OF THE DISTAL MOTOR AXON IN DOGS

被引：20

作者：

GRIFFITHS, IR ^{[1
]}

DUNCAN, I ^{[1
]}

机构：

[1] MONTREAL GEN HOSP,DEPT NEUROL,MONTREAL H3G 1A4,QUEBEC,CANADA

来源：

JOURNAL OF SMALL ANIMAL PRACTICE | 1979年 / 20卷 / 10期

关键词：

D O I：

10.1111/j.1748-5827.1979.tb06666.x

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

A group of ten dogs affected by an apparently identical denervating disease, is described. There was no breed or age predisposition but females were preferentially affected (70%). The rate of onset of signs was variable from a week to greater than 1 month. Quadriparesis was present to varying severities and in two dogs the head and neck could not be supported. Mastication, swallowing, respiration and bladder function were unimpaired. Pain sensation was normal, tone was usually decreased and the local limb reflexes depressed or absent. Muscle atrophy was often prominent. All cases bar one recovered but another dog was also destroyed. Electrophysiology revealed diffuse spontaneous activity in the muscles and the motor nerve conduction velocities were at the lower end of or just below the normal range. The evoked muscle potentials were reduced in amplitude. Sensory nerve potentials were normal. The pathology showed a degeneration of the distal intramuscular axons with collateral axonal sprouting. The muscle changes were typical of neurogenic atrophy. The disease has been called distal denervating disease (DDD) until the precise aetiology can be determined. © 1979 British Small Animal Veterinary Association

引用

页码：579 / 592

页数：14

共 15 条

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