ORTHO-HYDROXYPHENYLACETALDEHYDE - A MAJOR NOVEL METABOLITE OF COUMARIN FORMED BY RAT, GERBIL AND HUMAN LIVER-MICROSOMES

被引：32

作者：

FENTEM, JH ^{[1
]}

FRY, JR ^{[1
]}

WHITING, DA ^{[1
]}

机构：

[1] UNIV NOTTINGHAM,DEPT CHEM,NOTTINGHAM NG7 2RD,ENGLAND

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 179卷 / 01期

关键词：

D O I：

10.1016/0006-291X(91)91354-F

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A major novel coumarin metabolite was isolated from rat hepatic microsomal incubations by high-performance liquid chromatography. In the presence of a rat liver cytosolic fraction and NADH it was rapidly metabolized to o-hydroxyphenylethanol. The metabolite co-chromatographed with an authentic sample of o-hydroxyphenylacetaldehyde and its identity was confirmed by mass spectral analysis. The formation of o-hydroxyphenyl acetaldehyde from coumarin was NADPH-dependent. It was the major metabolite formed by rat, gerbil and human liver microsomes at a coumarin concentration of 1mM. © 1991.

引用

页码：197 / 203

页数：7

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