PLATELET BEHAVIOR AND HEMOSTATIC VARIABLES IN TYPE-1 (INSULIN-DEPENDENT) DIABETIC-PATIENTS WITH AND WITHOUT ALBUMINURIA

被引：14

作者：

ODONNELL, MJ ^{[1
]}

LEGUEN, CA ^{[1
]}

LAWSON, N ^{[1
]}

GYDE, OHB ^{[1
]}

BARNETT, AH ^{[1
]}

机构：

[1] E BIRMINGHAM DIST GEN HOSP,UNDERGRAD TEACHING CTR,BORDESLEY GREEN E,BIRMINGHAM B9 5ST,W MIDLANDS,ENGLAND

来源：

DIABETIC MEDICINE | 1991年 / 8卷 / 07期

关键词：

DIABETES-MELLITUS; PLATELETS; BETA-THROMBOGLOBULIN; PLATELET FACTOR-IV ALBUMINURIA; RETINOPATHY; NEPHROPATHY; FIBRINOGEN; FACTOR-VIIIC;

D O I：

10.1111/j.1464-5491.1991.tb01668.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Abnormalities of haemostasis have been implicated in the development of both large and small vessel disease in diabetes. Platelet behaviour and coagulation factors were studied in 28 non-diabetic control subjects and 81 Type 1 diabetic patients with different degrees of albuminuria. Twenty-four (30 %) patients had macro- or micro-albuminuria. These patients had elevated levels of beta-thromboglobulin compared with normo-albuminuric patients and control subjects (macro-albuminuric 113 (range 60-314), micro-albuminuric 88 (50-220), normo-albuminuric 55 (13-273), control 52 (18-210)-mu-g l-1, p < 0.001). Similar results were found for platelet factor 4 (macro-albuminuric 57 (9-350), micro-albuminuric 78 (12-205), normo-albuminuric 10 (2-135), control 9 (3-95)-mu-g l-1, p < 0.001). There were decreased beta-thromboglobulin:platelet factor 4 ratios in the albuminuric patients compared with control subjects and normo-albuminuric patients (p < 0.001). There is abnormal platelet activity in Type 1 diabetic patients with elevated albumin excretion rates.

引用

页码：624 / 628

页数：5

共 40 条

[1]

Barbosa J., Saner B., Do genetic factors play a role in the pathogenesis of microangiopathy?, Diabetologia, 27, pp. 487-492, (1984)

[2]

Barnett AH, Pyke D., The genetics of diabetic complications, Clin Endocrinol Metab, 15, pp. 715-726, (1986)

[3]

Jennings PEJ, Barnett AH, New approaches to the pathogenesis and treatment of diabetic microangiopathy, Diabetic Med, 5, pp. 111-117, (1988)

[4]

Colwell J., Halushka P., Platelets, prostaglandins and coagulation in diabetes mellitus, Mt Sinai J Med, 49, pp. 215-222, (1982)

[5]

Hockaday TDR, Direct animal and indirect human evidence of altered platelet function in diabetes mellitus, Metabolism, 128, pp. 415-422, (1979)

[6]

Colwell J., Halushka P., Platelet function and diabetes mellitus, Med Clin North Am, 62, pp. 753-766, (1978)

[7]

Colwell J., Halushka P., Platelet function in diabetes mellitus, Br J Haematol, 44, pp. 521-526, (1980)

[8]

Betteridge DJ, Zahavi J., Jones NAG, Shine B., Kakkar VV, Galton DJ, Platelet function in diabetes mellitus in relationship to complications, glycosylated haemoglobin and serum lipoproteins, Eur J Clin Invest, 11, pp. 273-277, (1981)

[9]

Corbella E., Miragliotta G., Masperi R., Villa S., Bini A., de Gaetano G., Et al., Platelet aggregation and antithrombin III levels in diabetic children, Haemostasis, 8, pp. 30-37, (1979)

[10]

Brooks AVM, Hussein S., Chesterman CN, Martin JF, Alford FP, Penington DG, Platelets, coagulation and fibrinolysis in patients with diabetic retinopathy, Thromb Haemostas (Stuttgart), 49, pp. 123-127, (1983)

← 1 2 3 4 →