EFFECT OF VASOACTIVE AMINES ON WEIBEL-PALADE BODIES IN CAPILLARY ENDOTHELIAL-CELLS

被引：8

作者：

DIKRANIAN, K

STOINOV, N

机构：

[1] Department of Anatomy and Histology, Institute of Medicine, Varna

来源：

EXPERIENTIA | 1991年 / 47卷 / 08期

关键词：

CAPILLARY; ENDOTHELIAL CELL; MUCOSA; WEIBEL-PALADE BODY; VON WILLEBRAND FACTOR; ELECTRON MICROSCOPY; RAT;

D O I：

10.1007/BF01922465

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The presence and distribution of Weibel-Palade bodies in stomach and colonic mucosal microvessels after the administration of vasoactive amines (serotonin and histamine), the serotonin depletor reserpine, and the von Willebrand factor secretagogue thrombin, was studied by transmission electron microscopy. These agents elevated the number of Weibel-Palade bodies in all microvascular endothelial cells and especially in capillaries. It is concluded that vasoactive amines enhance the synthesis and secretion of large von Willebrand protein multimers by endothelial cells.

引用

页码：830 / 832

页数：3

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