HIGHLY EFFICIENT NUCLEOPHILIC-ADDITION OF ALKYL GRIGNARD-REAGENTS TO 17-KETOSTEROIDS IN THE PRESENCE OF CERIUM(III) CHLORIDE - SYNTHESIS OF 17-ALPHA-PROPYL-17-BETA-HYDROXY-4-ANDROSTEN-3-ONE, AN ANDROGEN RECEPTOR ANTAGONIST

被引：19

作者：

LI, X ^{[1
]}

SINGH, SM ^{[1
]}

LABRIE, F ^{[1
]}

机构：

[1] CHUL, RES CTR, DIV MED CHEM, MOLEC ENDOCRINOL LAB, QUEBEC CITY G1V 4G2, PQ, CANADA

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 08期

关键词：

D O I：

10.1016/0040-4039(94)88011-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The addition of alkyl Grignard reagents to sterically hindered 17-ketosteroids was significantly enhanced by anhydrous cerium(lII) chloride with notable suppression of abnormal reactions, while the addition products were obtained in good to excellent yields and high stereoselectivity.

引用

页码：1157 / 1160

页数：4

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