APOPTOTIC SIGNALS DELIVERED THROUGH THE T-CELL RECEPTOR OF A T-CELL HYBRID REQUIRE THE IMMEDIATE-EARLY GENE NUR77

被引:500
作者
LIU, ZG
SMITH, SW
MCLAUGHLIN, KA
SCHWARTZ, LM
OSBORNE, BA
机构
[1] UNIV MASSACHUSETTS,DEPT VET & ANIM SCI,AMHERST,MA 01003
[2] UNIV MASSACHUSETTS,DEPT BIOL,AMHERST,MA 01003
[3] UNIV MASSACHUSETTS,PROGRAM MOLEC & CELLULAR BIOL,AMHERST,MA 01003
关键词
D O I
10.1038/367281a0
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
ENGAGEMENT of the T-cell antigen receptor (TCR) on immature thymic T cells induces death by apoptosis1-3. Although several lines of evidence indicate that apoptosis requires de novo gene expression, little is known about the molecular pathways that mediate this response. Here we show that nur77 (refs 4-7), a zinc-finger transcription factor, is expressed in response to TCR engagement in immature T cells and T-cell hybrids. Antisense inhibition of nur77 expression prevents apoptosis in TCR-stimulated cells. nur 7 is also expressed in response to mitogens, but in this case transcription is regulated by 5' upstream elements that are distinct from those used for induction of apoptosis. In addition, polyadenylation is only observed on nur77 transcripts found in condemned cells. These data support a role for nur77 in cell death that may be distinct from that of activation.
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页码:281 / 284
页数:4
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