ENGAGEMENT of the T-cell antigen receptor (TCR) on immature thymic T cells induces death by apoptosis1-3. Although several lines of evidence indicate that apoptosis requires de novo gene expression, little is known about the molecular pathways that mediate this response. Here we show that nur77 (refs 4-7), a zinc-finger transcription factor, is expressed in response to TCR engagement in immature T cells and T-cell hybrids. Antisense inhibition of nur77 expression prevents apoptosis in TCR-stimulated cells. nur 7 is also expressed in response to mitogens, but in this case transcription is regulated by 5' upstream elements that are distinct from those used for induction of apoptosis. In addition, polyadenylation is only observed on nur77 transcripts found in condemned cells. These data support a role for nur77 in cell death that may be distinct from that of activation.
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US FDA, CTR DRUGS & BIOL, OFF BIOL RES & REV, DIV BIOCHEM & BIOPHYS, BETHESDA, MD 20892 USAUS FDA, CTR DRUGS & BIOL, OFF BIOL RES & REV, DIV BIOCHEM & BIOPHYS, BETHESDA, MD 20892 USA
ASHWELL, JD
CUNNINGHAM, RE
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US FDA, CTR DRUGS & BIOL, OFF BIOL RES & REV, DIV BIOCHEM & BIOPHYS, BETHESDA, MD 20892 USAUS FDA, CTR DRUGS & BIOL, OFF BIOL RES & REV, DIV BIOCHEM & BIOPHYS, BETHESDA, MD 20892 USA
CUNNINGHAM, RE
NOGUCHI, PD
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US FDA, CTR DRUGS & BIOL, OFF BIOL RES & REV, DIV BIOCHEM & BIOPHYS, BETHESDA, MD 20892 USAUS FDA, CTR DRUGS & BIOL, OFF BIOL RES & REV, DIV BIOCHEM & BIOPHYS, BETHESDA, MD 20892 USA
NOGUCHI, PD
HERNANDEZ, D
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US FDA, CTR DRUGS & BIOL, OFF BIOL RES & REV, DIV BIOCHEM & BIOPHYS, BETHESDA, MD 20892 USAUS FDA, CTR DRUGS & BIOL, OFF BIOL RES & REV, DIV BIOCHEM & BIOPHYS, BETHESDA, MD 20892 USA
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US FDA, CTR DRUGS & BIOL, OFF BIOL RES & REV, DIV BIOCHEM & BIOPHYS, BETHESDA, MD 20892 USAUS FDA, CTR DRUGS & BIOL, OFF BIOL RES & REV, DIV BIOCHEM & BIOPHYS, BETHESDA, MD 20892 USA
ASHWELL, JD
CUNNINGHAM, RE
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US FDA, CTR DRUGS & BIOL, OFF BIOL RES & REV, DIV BIOCHEM & BIOPHYS, BETHESDA, MD 20892 USAUS FDA, CTR DRUGS & BIOL, OFF BIOL RES & REV, DIV BIOCHEM & BIOPHYS, BETHESDA, MD 20892 USA
CUNNINGHAM, RE
NOGUCHI, PD
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h-index: 0
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US FDA, CTR DRUGS & BIOL, OFF BIOL RES & REV, DIV BIOCHEM & BIOPHYS, BETHESDA, MD 20892 USAUS FDA, CTR DRUGS & BIOL, OFF BIOL RES & REV, DIV BIOCHEM & BIOPHYS, BETHESDA, MD 20892 USA
NOGUCHI, PD
HERNANDEZ, D
论文数: 0引用数: 0
h-index: 0
机构:
US FDA, CTR DRUGS & BIOL, OFF BIOL RES & REV, DIV BIOCHEM & BIOPHYS, BETHESDA, MD 20892 USAUS FDA, CTR DRUGS & BIOL, OFF BIOL RES & REV, DIV BIOCHEM & BIOPHYS, BETHESDA, MD 20892 USA