ANTIBIOTICS ALTER METHOTREXATE METABOLISM AND EXCRETION

被引：72

作者：

ZAHARKO, DS

BRUCKNER, H

OLIVERIO, VT

机构：

[1] Laboratory of Chemical Pharmacology, National Cancer Institute, Bethesda

来源：

SCIENCE | 1969年 / 166卷 / 3907期

关键词：

D O I：

10.1126/science.166.3907.887

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The chemotherapeutic agent methotrexate is metabolized by the intestinal flora of normal mice. This metabolism is reduced either by treatment of mice with the antibiotics neomycin and sulfathiazole, or in germ-free mice. In addition to affecting metabolism, these antibiotics alter physiological distribution of methotrexate so that excretion by the intestinal route is significantly enhanced.

引用

页码：887 / &

共 10 条

[1]

BRUCKNER H, 1969, FED PROC, V28, P263

[2]

COATES ME, 1968, GERM FREE ANIMAL RES, P145

[3] ENZYMATIC HYDROLYSIS OF FOLATE ANALOGUES [J].