COMPARISON OF OFLOXACIN, GENTAMICIN, AND TOBRAMYCIN CONCENTRATIONS IN TEARS AND INVITRO MICS FOR 90-PERCENT OF TEST ORGANISMS

被引：31

作者：

RICHMAN, J ^{[1
]}

ZOLEZIO, H ^{[1
]}

TANGLIU, D ^{[1
]}

机构：

[1] ALLERGAN PHARMACEUT INC,2525 DUPONT DR,IRVINE,CA 92715

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1990年 / 34卷 / 08期

关键词：

D O I：

10.1128/AAC.34.8.1602

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Concentrations of three anti-infective agents in tear film were monitored after one topical application in rabbits. Ofloxacin concentrations exceeded the MIC for 90% of the organisms tested (MIC90) (gram-negative and gram-positive organisms) for 240 min. Tobramycin concentrations exceeded the MIC90 for 10 min. Gentamicin concentrations exceeded the MIC90 for 20 min for gram-positive organisms and 120 min for gram-negative organisms.

引用

页码：1602 / 1604

页数：3

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