TUMOR PROMOTERS INDUCE MEMBRANE CHANGES DETECTED BY FLUORESCENCE POLARIZATION

被引：75

作者：

FISHER, PB

FLAMM, M

SCHACHTER, D

WEINSTEIN, IB

机构：

[1] COLUMBIA UNIV,COLL PHYS & SURG,INST CANC RES,DEPT MED,NEW YORK,NY 10032

[2] COLUMBIA UNIV,COLL PHYS & SURG,DIV ENVIRONM SCI,NEW YORK,NY 10032

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 86卷 / 04期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0006-291X(79)90225-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The probe, 1,6-diphenyl-1,3,5-hexatriene (DPH) was used to determine if tumor promoting agents alter cell membranes. The active tumor promoters TPA (12-0-tetra-decanoyl-phorbol-13-acetate), PDD (phorbol-12,13-didecanoate) and PDB (phorbol-12,13-dibenzoate) were found to decrease fluorescence polarization of DPH in rat embryo cells, whereas the inactive tumor promoting compounds phorbol and 4α-PDD failed to induce this change. © 1979.

引用

页码：1063 / 1068

页数：6

共 27 条

[1] BERENBLUM I, 1975, CANCER COMPREHENSIVE, V1, P323
[2] EFFECT OF A PHORBOL ESTER ON A TRANSFORMATION-SENSITIVE SURFACE PROTEIN OF CHICK FIBROBLASTS
BLUMBERG, PM
DRIEDGER, PE
ROSSOW, PW
[J]. NATURE, 1976, 264 (5585) : 446 - 447
[3] Boutwell R K, 1974, CRC Crit Rev Toxicol, V2, P419
[4] CHEN LA, 1977, J BIOL CHEM, V252, P2163
[5] GROWTH STIMULATION OF HUMAN DIPLOID FIBROBLASTS BY TUMOR PROMOTER, 12-O-TETRADECANOYL-PHORBOL-13-ACETATE
DIAMOND, L
OBRIEN, S
DONALDSON, C
SHIMIZU, Y
[J]. INTERNATIONAL JOURNAL OF CANCER, 1974, 13 (05) : 721 - 730
[6] DRIEDGER PE, 1977, CANCER RES, V37, P3257
[7] PLAQUE PRODUCTION BY THE POLYOMA VIRUS
DULBECCO, R
FREEMAN, G
[J]. VIROLOGY, 1959, 8 (03) : 396 - 397
[8] PLAQUE FORMATION AND ISOLATION OF PURE LINES WITH POLIOMYELITIS VIRUSES
DULBECCO, R
VOGT, M
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1954, 99 (02) : 167 - 182
[9] FISHER P B, 1977, TCA (Tissue Culture Association) Manual, V3, P625, DOI 10.1007/BF00918505
[10] HECKER E, 1975, HDB ALLGEMEINEN PATH, V4, P651

← 1 2 3 →