EXPRESSION OF GENES ENCODING 2 CHAINS OF THE COLLAGEN TYPE-VI MOLECULE DURING HUMAN FETAL HEART DEVELOPMENT

被引：22

作者：

DUFF, K ^{[1
]}

WILLIAMSON, R ^{[1
]}

RICHARDS, SJ ^{[1
]}

机构：

[1] ST MARYS HOSP,SCH MED,DEPT BIOCHEM & MOLEC GENET,LONDON,ENGLAND

来源：

INTERNATIONAL JOURNAL OF CARDIOLOGY | 1990年 / 27卷 / 01期

基金：

英国医学研究理事会;

关键词：

Collagen type VI; Heart development;

D O I：

10.1016/0167-5273(90)90202-G

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Northern blot analysis was used to demonstrate the expression of genes encoding two chains of the extracellular matrix molecule, collagen type VI, in human fetal heart tissue. Both genes have been mapped to the Down's obligate region of chromosome 21. As congenital heart malformations are a common feature of Down's syndrome, developmentally regulated structural protein genes encoded by chromosome 21 are being investigated. © 1990.

引用

页码：128 / 129

页数：2

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