SYNTHESIS OF CARBORANES CONTAINING NUCLEOSIDE BASES - UNEXPECTEDLY HIGH CYTOSTATIC AND CYTOCIDAL TOXICITY TOWARDS CANCER-CELLS

被引：76

作者：

YAMAMOTO, Y ^{[1
]}

SEKO, T ^{[1
]}

NAKAMURA, H ^{[1
]}

NEMOTO, H ^{[1
]}

HOJO, H ^{[1
]}

MUKAI, N ^{[1
]}

HASHIMOTO, Y ^{[1
]}

机构：

[1] TOHOKU UNIV,INST PHARMACEUT,SENDAI,MIYAGI 980,JAPAN

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1992年 / 02期

关键词：

D O I：

10.1039/c39920000157

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

5-Carboranyluridine 1,5-carboranyldeoxyuridine 2 and 5-hydroxymethylcarboranyluridine 3 have been prepared; they show unexpectedly high cytotoxicity towards cancer cells, with IC50 values being ca. 10(-5) mol dm-3.

引用

页码：157 / 158

页数：2

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