MURINE ST2 GENE IS A MEMBER OF THE PRIMARY RESPONSE GENE FAMILY INDUCED BY GROWTH-FACTORS

被引：38

作者：

YANAGISAWA, K ^{[1
]}

TSUKAMOTO, T ^{[1
]}

TAKAGI, T ^{[1
]}

TOMINAGA, S ^{[1
]}

机构：

[1] JICHI MED SCH,DEPT BIOCHEM 2,3311-1 YAKUSHIJI,MINAMI KAWACHI,TOCHIGI 32904,JAPAN

来源：

FEBS LETTERS | 1992年 / 302卷 / 01期

关键词：

CELL CYCLE; PRIMARY RESPONSE GENE; INTERLEUKIN-I RECEPTOR; IMMUNOGLOBULIN SUPERFAMILY; CELL GROWTH;

D O I：

10.1016/0014-5793(92)80282-L

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The murine ST2 gene, which encodes a protein remarkably similar to the extracellular portion of murine interleukin 1 receptor types 1 and 2, is expressed in growth-stimulated BALB/c-3T3 cells in the presence of 50-mu-g/ml of cycloheximide. The treatment with 1,000 U/ml of purified native murine beta-interferon superinduced, rather than suppressed, the ST2 mRNA expression as in the cases of c-myc and JE mRNAs. These results suggested that the murine ST2 gene belongs to the family of primary response genes induced by growth factors. Furthermore, a longer ST2-related mRNA was found in BALB/c-3T3 cells that were stimulated to proliferate in the presence of cycloheximide.

引用

页码：51 / 53

页数：3

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