EFFECT OF INTRANIGRAL MN-2+ ON STRIATAL AND NIGRAL SYNTHESIS AND LEVELS OF DOPAMINE AND COFACTOR

被引：23

作者：

DANIELS, AJ ^{[1
]}

ABARCA, J ^{[1
]}

机构：

[1] CATHOLIC UNIV CHILE,DEPT CELL BIOL,SANTIAGO,CHILE

来源：

NEUROTOXICOLOGY AND TERATOLOGY | 1991年 / 13卷 / 05期

关键词：

MANGANESE NEUROTOXICITY; STRIATAL DOPAMINE SYNTHESIS; TETRAHYDROBIOPTERIN COFACTOR; TYROSINE HYDROXYLATION; GTP CYCLOHYDROLASE; NIGRO-STRIATAL DOPAMINERGIC PATHWAY;

D O I：

10.1016/0892-0362(91)90053-Y

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A single injection of manganese chloride into the rat substantia nigra caused a significant and reversible drop in nigral and striatal dopamine and cofactor content ipsilateral to the lesion. Maximal decrease, in both tissues, was observed 60 days after the lesion, and showed complete recovery at 90 days. In vivo striatal tyrosine hydroxylation and GTP cyclohydrolase activities were also decreased maximally at 60 days and were recovered by 90 days after the lesion. No effects were observed on the side contralateral to the injection.

引用

页码：483 / 487

页数：5

共 23 条

[1]

ABOUDONIA MM, 1983, CHEM BIOL PTERIDINES, P777

[2]

BONILLA E, 1980, NEUROTOXICOL TERATOL, V2, P37

[3] SIMULTANEOUS MEASUREMENT OF TYROSINE AND TRYPTOPHAN HYDROXYLASE-ACTIVITIES IN BRAIN IN-VIVO USING AN INHIBITOR OF AROMATIC AMINO-ACID DECARBOXYLASE [J].