STRUCTURAL COMPARISON OF UREASE AND A GROEL ANALOG FROM HELICOBACTER-PYLORI

被引:29
作者
AUSTIN, JW
DOIG, P
STEWART, M
TRUST, TJ
机构
[1] UNIV VICTORIA,DEPT BIOCHEM & MICROBIOL,VICTORIA V8W 3P6,BC,CANADA
[2] UNIV VICTORIA,CANADIAN BACTERIAL DIS NETWORK,VICTORIA V8W 3P6,BC,CANADA
[3] MRC,MOLEC BIOL LAB,CAMBRIDGE CB2 2QH,ENGLAND
关键词
D O I
10.1128/jb.174.22.7470-7473.1992
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Electron microscopy of purified protein preparations indicated that Helicobacter pylori urease consisted of circular particles that are 13 nm in diameter, some of which showed indications of threefold rotational symmetry. A GroEL analog of H. pylori (Hp60K) appeared as a disc-shaped molecule with a diameter similar to that of urease but possessed sevenfold rotational symmetry. In a side-view projection, Hp60K appeared as two or four discs stacked side by side.
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页码:7470 / 7473
页数:4
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