C-ERBB3 GENE ENCODES SECRETED AS WELL AS TRANSMEMBRANE RECEPTOR TYROSINE KINASE

被引：61

作者：

KATOH, M ^{[1
]}

YAZAKI, Y ^{[1
]}

SUGIMURA, T ^{[1
]}

TERADA, M ^{[1
]}

机构：

[1] UNIV TOKYO, FAC MED,DEPT INTERNAL MED 3,HONGO 7-3-1,BUNKYO KU, TOKYO 113, JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 192卷 / 03期

关键词：

D O I：

10.1006/bbrc.1993.1542

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

c-erbB3 product is moderately expressed in gastric mucosa, especially in parietal cells. Northern blot analysis revealed that 6.2-kb c-erb83 transcnpt was expressed in all gasteric cancer cell lines examined, and that 1.4-kb c-erbB3 transcnpt was expressed as highly as 6.2-kb transcript in MKN45 cells. erbB3-S cDNA, corresponding to 1.4-kb c-erbB3 transcript, was cloned by rapid amplification of cDNA ends. Sequence analysis of erbB3-S cDNA showed that this 1.4-kb c-erbB3 mRNA encoded a secreted receptor. Analysis of partial genomic structure of c-erbB3 gene revealed that the exon specific to secreted receptor was identical with the 5′ portion of the intron in c-erbB3 gene. c-erbB3 gene encodes secreted as well as transmembrane receptor tyrosine kinase due to alternative splicing. © 1993 Academic Press. All rights reserved.

引用

页码：1189 / 1197

页数：9

共 32 条

[1] GROWTH-FACTORS AND CANCER
AARONSON, SA
[J]. SCIENCE, 1991, 254 (5035) : 1146 - 1153
[2] ALTERNATIVE SPLICING - A UBIQUITOUS MECHANISM FOR THE GENERATION OF MULTIPLE PROTEIN ISOFORMS FROM SINGLE GENES
BREITBART, RE
ANDREADIS, A
NADALGINARD, B
[J]. ANNUAL REVIEW OF BIOCHEMISTRY, 1987, 56 : 467 - 495
[3] CHAN AML, 1987, ONCOGENE, V1, P229
[4] Frohman M.A., 1990, PCR PROTOCOLS GUIDE, P28
[5] 3 DIFFERENT MESSENGER-RNAS ENCODING HUMAN GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR
FUKUNAGA, R
SETO, Y
MIZUSHIMA, S
NAGATA, S
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (22) : 8702 - 8706
[6] K-SAM, AN AMPLIFIED GENE IN STOMACH-CANCER, IS A MEMBER OF THE HEPARIN-BINDING GROWTH-FACTOR RECEPTOR GENES
HATTORI, Y
ODAGIRI, H
NAKATANI, H
MIYAGAWA, K
NAITO, K
SAKAMOTO, H
KATOH, O
YOSHIDA, T
SUGIMURA, T
TERADA, M
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (15) : 5983 - 5987
[7] DIVERSE FORMS OF A RECEPTOR FOR ACIDIC AND BASIC FIBROBLAST GROWTH-FACTORS
JOHNSON, DE
LEE, PL
LU, J
WILLIAMS, LT
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1990, 10 (09) : 4728 - 4736
[8] HELICOBACTER-PYLORI MAY BE TRANSMITTED THROUGH GASTROFIBERSCOPE EVEN AFTER MANUAL HYAMINE WASHING
KATOH, M
SAITO, D
NODA, T
YOSHIDA, S
OGURO, Y
YAZAKI, Y
SUGIMURA, T
TERADA, M
[J]. JAPANESE JOURNAL OF CANCER RESEARCH, 1993, 84 (02): : 117 - 119
[9] K-SAM GENE ENCODES SECRETED AS WELL AS TRANSMEMBRANE RECEPTOR TYROSINE KINASE
KATOH, M
HATTORI, Y
SASAKI, H
TANAKA, M
SUGANO, K
YAZAKI, Y
SUGIMURA, T
TERADA, M
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (07) : 2960 - 2964
[10] INHIBITION OF THYROID-HORMONE ACTION BY A NON-HORMONE BINDING C-ERBA PROTEIN GENERATED BY ALTERNATIVE MESSENGER-RNA SPLICING
KOENIG, RJ
LAZAR, MA
HODIN, RA
BRENT, GA
LARSEN, PR
CHIN, WW
MOORE, DD
[J]. NATURE, 1989, 337 (6208) : 659 - 661

← 1 2 3 4 →