POLARITY OF MEIOTIC GENE CONVERSION IN FUNGI - CONTRASTING VIEWS

被引：60

作者：

NICOLAS, A ^{[1
]}

PETES, TD ^{[1
]}

机构：

[1] UNIV N CAROLINA,DEPT BIOL,CHAPEL HILL,NC 27599

来源：

EXPERIENTIA | 1994年 / 50卷 / 03期

关键词：

RECOMBINATION; MEIOSIS; GENE CONVERSION; POLARITY; HETERODUPLEX DNA; MISMATCH REPAIR; FUNGI;

D O I：

10.1007/BF01924007

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The frequency of meiotic gene conversion often varies linearly from one end of the gene to the other. This phenomenon has been called 'polarity'. In this review, we will primarily discuss studies of polarity that have been done in the yeast Sacchacromyces cerevisiae (ARG4 and HIS4 loci) and in Ascobolus (b2 locus) with an emphasis on possible mechanisms. The genetic and physical data obtained at these 'hotspots' of recombination strongly suggests that the formation of a polarity gradient reflects both the frequency of heteroduplex formation and the processing of this recombination intermediate by mismatch-repair-dependent processes.

引用

页码：242 / 252

页数：11

共 60 条

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