STRUCTURE OF THE INT-5, A NOVEL MMTV INTEGRATION GENOMIC LOCUS CONTAINING MOUSE EARLY TRANSPOSON LTR HOMOLOGY REGION

被引：5

作者：

DURGAM, VR ^{[1
]}

EASTON, JA ^{[1
]}

SURYA, R ^{[1
]}

TEKMAL, RR ^{[1
]}

机构：

[1] UNIV TEXAS, HLTH SCI CTR, DEPT OBSTET & GYNECOL, SAN ANTONIO, TX 78284 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 1995年 / 1263卷 / 01期

关键词：

INT GENE; MAMMARY TUMOR; EARLY TRANSPOSON; METN EXPRESSION; (MOUSE);

D O I：

10.1016/0167-4781(95)00093-V

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Previous studies have reported the cloning and identification of the int-5, a novel mouse mammary tumor virus (MMTV) integration locus involved in mammary tumorigenesis. Here we report the characterization of the 5.5 kb region from this novel MMTV integration site. Our results show that the region after the MMTV integration site, a 258 bp sequence is homologous (100%) to the mouse early transposon (mETn) long-terminal repeat and other sequences of the this transposon are not present in the 5.5 kb region. Our results also show for the first time the tumor specific expression of mETn and expression of the region downstream of the MMTV integration site that is homologous to mETn-LTR in D2 mammary tumors.

引用

页码：89 / 92

页数：4

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