INFLUENCE OF POINT MUTATIONS ON PROTEIN-STRUCTURE - PROBABILITY OF AF A NEUTRAL MUTATION

被引：30

作者：

SHAKHNOVICH, EI ^{[1
]}

GUTIN, AM ^{[1
]}

机构：

[1] ACAD SCI USSR,INST PROT RES,PUSHCHINO 142292,USSR

来源：

JOURNAL OF THEORETICAL BIOLOGY | 1991年 / 149卷 / 04期

关键词：

D O I：

10.1016/S0022-5193(05)80097-9

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We investigate the probability Xthat a random mutation (i.e. the substitution in a random site of one amino acid residue by randomly chosen residue) will be a neutral one, i.e. it will not lead to a change in structure. Using a random energy model for the description of protein energy "levels" we show that this, probability depends only on stiffness of a chain which is characterized by the number of conformations per peptide bond γ. The results X≈ γ-8. The application of this result for protein engineering experiments and for possible scenario of neutral evolution is discussed. © 1991 Academic Press Limited.

引用

页码：537 / 546

页数：10

共 13 条

[1] THEORY FOR THE FOLDING AND STABILITY OF GLOBULAR-PROTEINS [J].