NOVEL CONCEPTS IN DIRECTED BIARYL SYNTHESIS .12. 1ST ATROPO-ENANTIOSELECTIVE RING-OPENING OF ACHIRAL BIARYLS CONTAINING LACTONE BRIDGES WITH CHIRAL HYDRIDE-TRANSFER REAGENTS DERIVED FROM BORANE

被引：96

作者：

BRINGMANN, G

HARTUNG, T

机构：

[1] Institut Für Organische Chemie, Universität Würzburg, D-W-8700, Am Hubland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1992年 / 31卷 / 06期

关键词：

D O I：

10.1002/anie.199207611

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An impressive example of the directed "twisting" of bridged, configuratively labile biaryls with chiral H-nucleophiles is seen in the atropo-enantioselective, ring-open reduction of lactone 1 to alcohol 2 with borane . THF in the presence of the chiral oxazaborolidine 3. After one recrystallization 2 is enantiomerically pure.

引用

页码：761 / 762

页数：2

共 19 条

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