THE MYCOBACTERIUM-LEPRAE ANTIGEN-85 COMPLEX GENE FAMILY - IDENTIFICATION OF THE GENES FOR THE 85A, 85C, AND RELATED MPT51 PROTEINS

被引：36

作者：

DEWIT, TFR

BEKELIE, S

OSLAND, A

WIELES, B

JANSON, AAM

THOLE, JER

机构：

[1] LEIDEN UNIV HOSP, DEPT IMMUNOHAEMATOL, POB 9600, 2300 RC LEIDEN, NETHERLANDS

[2] UNIV ADDIS ABABA, ARMAUER HANSEN RES INST, ADDIS ABABA, ETHIOPIA

[3] UNIV ADDIS ABABA, DEPT BIOL, ADDIS ABABA, ETHIOPIA

来源：

INFECTION AND IMMUNITY | 1993年 / 61卷 / 09期

关键词：

D O I：

10.1128/IAI.61.9.3642-3647.1993

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The genes for two novel members (designated 85A and 85C) of the Mycobacterium leprae antigen 85 complex family of proteins and the gene for the closely related M. leprae MPT51 protein were isolated. The complete DNA sequence of the M. leprae 85C gene and partial sequences of the 85A and MPT51 genes are presented. As in M. tuberculosis, the M. leprae 85A, 85C, and previously identified 85B component genes are not closely linked on the genome. However, the MPT51 genes of both species localize close to the respective 85A component genes. Like the 85B component, the M. leprae 85A-MPT51 and 85C antigens are recognized by T cells from healthy contacts and leprosy patients.

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页码：3642 / 3647

页数：6

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