IDENTIFICATION OF NATURAL-KILLER ENHANCING FACTOR AS A MAJOR ANTIOXIDANT IN HUMAN RED-BLOOD-CELLS

被引：62

作者：

SHAU, HY ^{[1
]}

KIM, A ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES, MED CTR, JONSSON COMPREHENS CANC CTR, LOS ANGELES, CA 90024 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 199卷 / 01期

关键词：

D O I：

10.1006/bbrc.1994.1197

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human natural killer enhancing factor genes (NKEF-A and B) share extensive homology with several genes from other organisms known to be induced by oxidative stress and to protect organisms and proteins from oxidative destruction. In this study, we have identified natural killer enhancing factor as an abundant protein in red blood cell cytosol. Highly purified natural killer enhancing factor blocks inactivation of enzymes by mixed metal-thiol oxidation. Thus, natural killer enhancing factor is a major antioxidant protecting red blood cells from oxidative injuries. (C) 1994 Academic Press, Inc.

引用

页码：83 / 88

页数：6

共 14 条

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