STUDIES ON THE URINARY-EXCRETION OF THROMBOXANE B-2 IN ZELLWEGER PATIENTS AND CONTROL SUBJECTS - EVIDENCE FOR A MAJOR ROLE FOR PEROXISOMES IN THE BETA-OXIDATIVE CHAIN-SHORTENING OF THROMBOXANE B-2

被引：9

作者：

DEWAART, DR ^{[1
]}

KOOMEN, GCM ^{[1
]}

WANDERS, RJA ^{[1
]}

机构：

[1] UNIV AMSTERDAM,ACAD MED CTR,DEPT PEDIAT,1105 AZ AMSTERDAM,NETHERLANDS

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 1994年 / 1226卷 / 01期

关键词：

PEROXISOME; BETA-OXIDATION; THROMBOXANE; ZELLWEGER SYNDROME; EICOSANOID;

D O I：

10.1016/0925-4439(94)90057-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this paper we studied the urinary excretion of thromboxane B-2 and its beta-oxidation product 2,3-dinor-thromboxane B-2 in urines from control subjects and four Zellweger patients, which lack morphologically distinguishable peroxisomes. In the urine of three classical Zellweger patients we found a ratio of 2,3-dinor-thromboxane B-2/thromboxane B-2 of 0.35, 0.48 and 0.62 respectively, whereas in healthy children and adults values were found of 3.1-10 and 5.5-40 respectively. These data strongly suggest that peroxisomes are a major site for beta-oxidation of thromboxane B-2.

引用

页码：44 / 48

页数：5

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