LOCALIZATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) TO A GENE-CLUSTER ON CHROMOSOME 17Q

被引：4

作者：

LEWIS, TB

SAENZ, M

OCONNELL, P

LEACH, RJ

机构：

[1] UNIV TEXAS,HLTH SCI CTR,DEPT CELLULAR & STRUCT BIOL,SAN ANTONIO,TX 78284

[2] UNIV TEXAS,HLTH SCI CTR,DEPT PATHOL,SAN ANTONIO,TX 78284

来源：

GENOMICS | 1994年 / 19卷 / 03期

关键词：

D O I：

10.1006/geno.1994.1114

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Glucose-dependent insulinotropic polypeptide (GIP) has been regionally localized to a gene cluster on human chromosome 17q. Genetic mapping through CEPH reference families demonstrated that GIP was tightly linked to NME1 and PPY and fully linked to HOXB6 and NGFR. High-resolution radiation hybrid mapping resolved the gene order as cen-PPY-HOXB6-NGFR-GIP-NME1-tel. GIP maps distal to NGFR with an estimated distance of 250 kb. (C) 1994 Academic Press, Inc.

引用

页码：589 / 591

页数：3

共 12 条

[1] POLYMORPHIC DNA REGION ADJACENT TO THE 5'-END OF THE HUMAN INSULIN GENE [J].