ELECTRONIC-STRUCTURE AND REACTIVITY OF ORGANOFLUORINE COMPOUNDS .6. THE EFFECT OF THE POSITION OF THE CF3 GROUP ON THE BASICITY OF ALIPHATIC-AMINES

The basicity of isomeric bromoethylamines having a CF3 substituent in the alpha- and beta-positions with respect to the amino group was studied. According to potentiometric titration in H2O, CH3NO2, and CH3CN, the basicity of alpha-trifluoromethylamines is 4-5 orders of magnitude lower than that of beta-trifluoromethyl isomers. Quantum-chemical calculations (AM1) showed that the decrease in the basicity of alpha-trifluoromethylamines does not correlate with tile change in the electron density at the nitrogen atom.