A FAMILY CLUSTER OF AN IMMUNE ESCAPE VARIANT OF HEPATITIS-B VIRUS INFECTING A MOTHER AND HER 2 FULLY IMMUNIZED CHILDREN

被引：15

作者：

HO, MS ^{[1
]}

LU, CF ^{[1
]}

KUO, J ^{[1
]}

MAU, YC ^{[1
]}

CHAO, WH ^{[1
]}

机构：

[1] NATL INST PREVENT MED,DEPT HLTH,TAIPEI,TAIWAN

来源：

CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY | 1995年 / 2卷 / 06期

关键词：

D O I：

10.1128/CDLI.2.6.760-762.1995

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A hepatitis B virus (HBV) immune escape variant which results from a substitution of glycine by arginine at position 145 (arginine-145) in the immunodominant neutralization epitope of the S protein was found to infect one child in a seroepidemiologic survey of 1,812 vaccinated children. The child's mother and a younger brother were also infected by the same HBV variant, despite a greater than accepted level of protective antibody (anti-HBV surface antigen) in both the index child (30 mIU/ml) and the brother (>20,000 mIU/ml). Our findings suggest the perinatal or horizontal transmission of the arginine-145 HBV variant from mother to child, but the ability of this variant to propagate among the vaccinated children remains unknown.

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页码：760 / 762

页数：3

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