INHIBITION OF INFLAMMATORY RESPONSES BY EPITAONDIOL AND OTHER MARINE NATURAL-PRODUCTS

被引：32

作者：

GIL, B

FERRANDIZ, ML

SANZ, MJ

TERENCIO, MC

UBEDA, A

ROVIROSA, J

SANMARTIN, A

ALCARAZ, MJ

PAYA, M

机构：

[1] UNIV VALENCIA,DEPT PHARMACOL,E-46100 VALENCIA,SPAIN

[2] UNIV CHILE,FAC SCI,DEPT CHEM,SANTIAGO,CHILE

来源：

LIFE SCIENCES | 1995年 / 57卷 / 02期

关键词：

AND-INFLAMMATORY; MARINE NATURAL PRODUCTS; PHOSPHOLIPASE A(2); MYELOPEROXIDASE;

D O I：

10.1016/0024-3205(95)00260-D

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The marine metabolites pacifenol, stypotriol triacetate and epitaondiol were tested for their effects on a number of inflammatory responses. Epitaondiol exhibited a potent topical anti-inflammatory activity related to inhibition of leukocyte accumulation. The other compounds showed a lower potency, similar to that of indomethacin. None of the compounds affected superoxide generation by human neutrophils but pacifenol effectively inhibited the degranulation response. This compound and epitaondiol decreased the release of eicosanoids with a higher potency on the cyclo-oxygenase pathway. Only epitaondiol inhibited human recombinant synovial phospholipase A(2) activity in a concentration-dependent manner.

引用

页码：PL25 / PL30

页数：6

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