MECHANICAL FACTORS ASSOCIATED WITH THE DEVELOPMENT OF INTIMAL AND MEDIAL THICKENING IN VEIN GRAFTS SUBJECTED TO ARTERIAL-PRESSURE - A MODEL OF ARTERIES EXPOSED TO HYPERTENSION

被引:110
作者
DOBRIN, PB [1 ]
机构
[1] VET AFFAIRS EDWARD HINES JR HOSP,HINES,IL
关键词
DEFORMATION; STRESS; SHEAR STRESS; CIRCUMFERENTIAL STRESS; LONGITUDINAL STRESS; RADIAL DIRECTIONS;
D O I
10.1161/01.HYP.26.1.38
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Arteries exposed to sustained hypertension undergo a moderate degree of intimal thickening and a marked amount of medial thickening. Autogenous veins that are used as bypass grafts undergo similar histological changes. In this study autogenous vein grafts were used as an indirect model of arteries exposed to sustained hypertension. It was hypothesized that it is not pressure per se but rather mechanical changes brought about by exposure to increased pressures that act as a stimulus inducing histological changes. Exposure to arterial pressure increases the following nine mechanical factors: deformation in the circumferential, longitudinal, and radial directions; stresses in each of these three directions; pulsatile deformations and pulsatile stresses; and flow velocity. All of these mechanical changes occur simultaneously. Accordingly, a three-step algorithm was devised to separate each of the nine mechanical factors and correlate them with histological changes. Three sequential experimental studies were performed in 38 dogs following the algorithm. These experiments demonstrated that intimal thickening was best correlated with low flow velocity, a correlate of low shear stress, whereas medial thickening was best correlated with deformation in the circumferential direction.
引用
收藏
页码:38 / 43
页数:6
相关论文
共 11 条
[1]  
BANDICK NR, 1971, P SOC EXP BIOL MED, V134, P56
[2]   REDUCING PULSE PRESSURE IN HYPERTENSION MAY NORMALIZE SMALL ARTERY STRUCTURE [J].
CHRISTENSEN, KL .
HYPERTENSION, 1991, 18 (06) :722-727
[3]  
DOBRIN PB, 1989, SURGERY, V105, P393
[4]   MECHANICAL AND HISTOLOGIC-CHANGES IN CANINE VEIN GRAFTS [J].
DOBRIN, PB ;
LITTOOY, FN ;
GOLAN, J ;
BLAKEMAN, B ;
FAREED, J .
JOURNAL OF SURGICAL RESEARCH, 1988, 44 (03) :259-265
[5]  
EVANS LV, 1994, INTIMAL HYPERPLASIA, P111
[6]   EVIDENCE FOR IN-VIVO CAROTID AND FEMORAL WALL THICKENING IN HUMAN HYPERTENSION [J].
GARIEPY, J ;
MASSONNEAU, M ;
LEVENSON, J ;
HEUDES, D ;
SIMON, A .
HYPERTENSION, 1993, 22 (01) :111-118
[7]  
LEE RMKW, 1983, BLOOD VESSELS, V20, P72
[8]  
LEUNG DYM, 1976, SCIENCE, V191, P475
[9]   ALTERATIONS IN VASCULAR SMOOTH-MUSCLE MASS IN THE SPONTANEOUSLY HYPERTENSIVE RAT - ROLE OF CELLULAR HYPERTROPHY, HYPERPLOIDY, AND HYPERPLASIA [J].
OWENS, GK ;
SCHWARTZ, SM .
CIRCULATION RESEARCH, 1982, 51 (03) :280-289
[10]   MECHANICAL AND MORPHOLOGICAL PROPERTIES OF ARTERIAL RESISTANCE VESSELS IN YOUNG AND OLD SPONTANEOUSLY HYPERTENSIVE RATS [J].
WARSHAW, DM ;
MULVANY, MJ ;
HALPERN, W .
CIRCULATION RESEARCH, 1979, 45 (02) :250-259