STEPWISE HYDROGEN REMOVAL IN THE ENZYMATIC RING EXPANSION OF PENICILLIN-N TO DEACETOXYCEPHALOSPORIN-C

被引：20

作者：

BALDWIN, JE

ADLINGTON, RM

APLIN, RT

CROUCH, NP

SCHOFIELD, CJ

TING, HH

机构：

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1987年 / 21期

关键词：

D O I：

10.1039/c39870001654

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

引用

页码：1654 / 1656

页数：3

共 13 条

[1] CONVERSION OF O-17/O-18 LABELED DELTA-(L-ALPHA-AMINOADIPYL)-L-CYSTEINYL-D-VALINE TO O-17/O-18 LABELED ISOPENICILLIN-N IN A CELL-FREE-EXTRACT OF CEPHALOSPORIUM ACREMONIUM - A STUDY BY O-17-NMR SPECTROSCOPY AND MASS-SPECTROMETRY [J].

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[2] PENICILLIN BIOSYNTHESIS - ACTIVE-SITE MAPPING WITH AMINOADIPOYLCYSTEINYLVALINE VARIANTS [J].

BALDWIN, JE ;

ABRAHAM, EP ;

ADLINGTON, RM ;

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DOMAYNEHAYMAN, BP ;

FIELD, LD ;

FLITSCH, SL ;

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[3] PENICILLIN BIOSYNTHESIS - THE ORIGIN OF HYDROXY-GROUPS IN BETA-LACTAMS DERIVED FROM UNSATURATED SUBSTRATES [J].

BALDWIN, JE ;

ADLINGTON, RM ;

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JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1986, (17) :1305-1308

[4] RING EXPANSION OF PENAMS TO CEPHAMS - A POSSIBLE BIOMIMETIC PROCESS [J].

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[5] CEPHALOSPORIN-C BIOSYNTHESIS - A BRANCHED PATHWAY SENSITIVE TO A KINETIC ISOTOPE EFFECT [J].

BALDWIN, JE ;

ADLINGTON, RM ;

APLIN, RT ;

CROUCH, NP ;

KNIGHT, G ;

SCHOFIELD, CJ .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1987, (21) :1651-1654

[6] A STEREOCHEMICAL CONCEPT FOR THE CATALYTIC MECHANISM OF PROLYLHYDROXYLASE - APPLICABILITY TO CLASSIFICATION AND DESIGN OF INHIBITORS [J].

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[7] SYNTHESIS AND INCORPORATION OF (2S,3S)-[4-C-13]VALINE INTO BETA-LACTAM ANTIBIOTICS [J].

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[8] INCORPORATION OF (2RS,3S)-[4-C-13]VALINE INTO CEPHALOSPORIN-C [J].

NEUSS, N ;

NASH, CH ;

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LEMKE, PA ;

GRUTZNER, JB .

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[9] STEREOCHEMISTRY OF THE INCORPORATION OF VALINE METHYL-GROUPS INTO METHYLENE GROUPS IN CEPHALOSPORIN-C [J].

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BIOCHEMICAL JOURNAL, 1984, 222 (03) :777-788

[10] ALPHA-KETOGLUTARATE DEPENDENT DIOXYGENASES - MECHANISM FOR PROLYL HYDROXYLASE ACTION [J].

SIEGEL, B .

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