SYNTHESIS AND ANTIMICROBIAL ACTIVITIES OF 5-AMIDOBENZOTRIAZOLE DERIVATIVES

被引：4

作者：

CALIENDO, G

NOVELLINO, E

SAGLIOCCO, G

SANTAGADA, V

SILIPO, C

VITTORIA, A

机构：

[1] NAPLES UNIV,DEPARTIMENTO CHIM FARMACEUT & TOSSICOL,VIA D MONTESANO 49,I-80131 NAPLES,ITALY

[2] FAC MED & CHIRURG NAPLES,IST IGIENE & MED PREVENT,I-80131 NAPLES,ITALY

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1990年 / 25卷 / 04期

关键词：

antimicrobial activity; benzotriazoles; lipophilicity;

D O I：

10.1016/0223-5234(90)90118-M

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 2-cyclopentyl-5-amidobenzotriazole derivatives has been prepared and characterized. Shake-flask partition coefficients (log P) and capacity factors (log k1) were experimentally determined and correlated through regression analysis. The in vitro antimicrobial activity of prepared compounds against gram-positive, gram-negative bacteria and Candida albicans are discussed in function of their structural features. Some derivatives are characterized by interesting antimicrobial activities. © 1990.

引用

页码：343 / 350

页数：8

共 8 条

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