PURINE ANALOGS AS AMPLIFIERS OF PHLEOMYCIN .4. SOME PYRAZOLO[3,4-D]PYRIMIDINE, IMIDAZO[4,5-B]-PYRIDINE, IMIDAZO[4,5-C]PYRIDINE AND QUINAZOLINE DERIVATIVES

被引：14

作者：

BROWN, DJ ^{[1
]}

DANCKWERTS, L ^{[1
]}

GRIGG, GW ^{[1
]}

IWAI, Y ^{[1
]}

机构：

[1] CSIRO,MOLEC & CELLULAR BIOL UNIT,N RYDE 2113,NEW S WALES,AUSTRALIA

来源：

AUSTRALIAN JOURNAL OF CHEMISTRY | 1979年 / 32卷 / 02期

关键词：

D O I：

10.1071/CH9790453

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

1-Methyl-1H-pyrazolo[3, 4-d]pyrimidine-4(5H)-thione (1b), its 1-phenyl analogue (1c), 1H-pyrazolo-[3, 4-d]pyrimidine-4, 6(5H, 7H)-dithione (2a), its 1-methyl (2b) and 1-phenyl (2c) derivatives, 1H-imidazo[4, 5-b and 4, 5-c]pyridine-2(3H)-thiones (5) and (6), and quinazoline-4(3H)-thione (9) react with simple alkyl halides, 2-chloroacetamide, 2-chloro-N-methylacetamide or 2-bromopropionamide to give the corresponding thioethers (3e-n), (4a-1), (7a-c), (8a-d) and (10). The unmethylated amides among these show dual NH peaks in their n.m.r. spectra. Activities as amplifiers of phleomycin against E. coli are tabulated and discussed. © 1979, CSIRO. All rights reserved.

引用

页码：453 / 458

页数：6

共 35 条

[1] IONIZATION CONSTANTS OF HETEROCYCLIC SUBSTANCES .5. MERCAPTO-DERIVATIVES OF DIAZINES AND BENZODIAZINES
ALBERT, A
BARLIN, GB
[J]. JOURNAL OF THE CHEMICAL SOCIETY, 1962, (AUG): : 3129 - &
[2] PURINES AS AMPLIFIERS OF ANTIBIOTIC ACTIVITY OF PHLEOMYCIN AGAINST ESCHERICHIA-COLI-B
ANGYAL, AM
GRIGG, GW
BADGER, RJ
BROWN, DJ
LISTER, JH
[J]. JOURNAL OF GENERAL MICROBIOLOGY, 1974, 85 (NOV): : 163 - 168
[3] PURINE STUDIES .10. FURTHER SYNTHETIC APPROACHES TO PURINES FOR APPLICATION OF PHLEOMYCIN ACTIVITY AGAINST ESCHERICHIA-COLI
BADGER, RJ
BROWN, DJ
LISTER, JH
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1974, (01): : 152 - 158
[4] IONISATION CONSTANTS OF HETEROCYCLIC SUBSTANCES .8. 1,3,5-TRIAZAINDENES
BARLIN, GB
[J]. JOURNAL OF THE CHEMICAL SOCIETY B-PHYSICAL ORGANIC, 1966, (04): : 285 - &
[5] PREPARATION AND ELECTRONIC-SPECTRA OF MERCAPTOACETAMIDES
BHANDARI, CS
SOGANI, NC
MAHNOT, US
[J]. JOURNAL FUR PRAKTISCHE CHEMIE, 1971, 313 (05): : 849 - &
[6] PURINE STUDIES .17. SYNTHESIS OF 2-SUBSTITUTED 6,9-DIMETHYL AND 6,8,9-TRI-METHYLPURINES AS AMPLIFIERS OF PHLEOMYCIN
BHUSHAN, K
BROWN, DJ
LISTER, JH
STEPHANSON, LG
YONEDA, F
[J]. AUSTRALIAN JOURNAL OF CHEMISTRY, 1975, 28 (11) : 2553 - 2559
[7] BROWN DJ, 1978, AUST J CHEM, V31, P397, DOI 10.1071/CH9780397
[8] PURINE STUDIES .13. METABOLISM OF 2,9-DIMETHYL-8-METHYLTHIOPURINE AND 2-CARBAMOYLMETHYLTHIO-6,9-DIMETHYLPURINE IN MICE
BROWN, DJ
STEPHANSON, LG
[J]. AUSTRALIAN JOURNAL OF CHEMISTRY, 1974, 27 (06) : 1371 - 1375
[9] PURINE STUDIES .7. SYNTHESIS OF PURINES AS AMPLIFIERS OF PHLEOMYCIN AGAINST ESCHERICHIA-COLI
BROWN, DJ
ANGYAL, AM
JONES, RL
GRIGG, GW
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1972, (14): : 1819 - &
[10] THIAZOLO[5,4-D]PYRIMIDINE DERIVATIVES AS AMPLIFIERS OF PHLEOMYCIN AGAINST ESCHERICHIA-COLI
BROWN, DJ
DUNLAP, WC
GRIGG, GW
KELLY, J
[J]. AUSTRALIAN JOURNAL OF CHEMISTRY, 1977, 30 (08) : 1775 - 1783

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