SIMON METABOLITES OF ALPHA-TOCOPHEROL ARE NOT FORMED VIA A RATE-CONTROLLING SCISSION OF THE 3'C-H BOND

被引：8

作者：

DUTTON, PJ ^{[1
]}

HUGHES, LA ^{[1
]}

FOSTER, DO ^{[1
]}

BURTON, GW ^{[1
]}

INGOLD, KU ^{[1
]}

机构：

[1] NATL RES COUNCIL CANADA,STEACIE INST MOLEC SCI,OTTAWA K1A 0R6,ONTARIO,CANADA

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 1990年 / 9卷 / 05期

关键词：

SIMON METABOLITES; ALPHA-TOCOPHEROL; VITAMIN-E; COMPETITIVE UPTAKE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY;

D O I：

10.1016/0891-5849(90)90021-A

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The major in vivo oxidation products of alpha-tocopherol, alpha-T, are the Simon metabolities, 1 and 2. For these compounds to be formed from alpha-T the polyisoprenoid tail of alpha-T must be oxidatively cleaved at the 3' carbon atom. Comparison of the levels of 2R,4'R,8'R-alpha-(3',3'-H-2(2))-T and 2R,4'R,8'R-alpha-[C2H-3)2]-T remaining in various tissues of rats which had been preloaded with equal quantities of these two forms of vitamin E following a change to a vitamin E-free diet has shown that there is no statistically significant difference in the rates of loss of these two deuterium-labeled alpha-T's. This demonstrates that the Simon metabolites are not formed by a rate-controlling scission of the 3'C-H bond of alpha-T.

引用

页码：435 / 439

页数：5

共 26 条

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