ANDROGEN ACCUMULATION AND BINDING TO MACROMOLECULES IN SEMINAL VESICLES - INHIBITION BY CYPROTERONE

被引：97

作者：

STERN, JM

EISENFEL.AJ

机构：

[1] Institute of Animal Behavior, Rutgers University, Newark

[2] Departments of Pharmacology and Internal Medicine, Yale University, School of Medicine, New Haven

来源：

SCIENCE | 1969年 / 166卷 / 3902期

关键词：

D O I：

10.1126/science.166.3902.233

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cyproterone reduces the accumulation of testosterone and dihydrotestosterone in seminal vesicles 30 minutes after intravenous administration of tritiated testosterone to castrated rats. Testosterone, added in vitro, binds to macromolecules from the supernatant fraction of the seminal vesicle homogenates; this interaction is antagonized competitively by cyproterone. Cyproterone may diminish androgenic effects by competition for binding molecules.

引用

页码：233 / &

共 28 条

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