BETA-2-MICROGLOBULIN DEFICIENT MICE LACK CD4-8+ CYTOLYTIC T-CELLS

被引：961

作者：

ZIJLSTRA, M

BIX, M

SIMISTER, NE

LORING, JM

RAULET, DH

JAENISCH, R

机构：

[1] MIT,DEPT BIOL,CAMBRIDGE,MA 02142

[2] MIT,CTR CANC RES,CAMBRIDGE,MA 02142

来源：

NATURE | 1990年 / 344卷 / 6268期

关键词：

D O I：

10.1038/344742a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Mice homozygous for a β2-microglobulin gene disruption do not express any detectable β2-ITL protein. They express little if any functional major histocompatibility complex (MHC) class I antigen on the cell surface yet are fertile and apparently healthy. They show a normal distribution of γδ, CD4+8+ and CD4+8- cells, but have no mature CD4-8+ cells and are defective in CD4-8+ cell-mediated cytotoxicity. Our results strongly support earlier evidence that MHC class I molecules are crucial for positive selection of T cell antigen receptor αβ+ CD4-8+ T cells in the thymus and call into question the non-immune functions that have been ascribed to MHC class I molecules. © 1990 Nature Publishing Group.

引用

页码：742 / 746

页数：5

共 55 条

[1] BETA-2-MICROGLOBULIN IS NOT REQUIRED FOR CELL-SURFACE EXPRESSION OF THE MURINE CLASS-I HISTOCOMPATIBILITY ANTIGEN H-2DB OR OF A TRUNCATED H-2DB
ALLEN, H
FRASER, J
FLYER, D
CALVIN, S
FLAVELL, R
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (19) : 7447 - 7451
[2] EFFECT OF H-2 GENE COMPLEX RATES OF FIBROBLAST INTER-CELLULAR ADHESION
BARTLETT, PF
EDIDIN, M
[J]. JOURNAL OF CELL BIOLOGY, 1978, 77 (02) : 377 - 388
[3] BETA-2-MICROGLOBULIN FROM SERUM ASSOCIATES WITH MHC CLASS-I ANTIGENS ON THE SURFACE OF CULTURED-CELLS
BERNABEU, C
VANDERIJN, M
LERCH, PG
TERHORST, CP
[J]. NATURE, 1984, 308 (5960) : 642 - 645
[4] BEVAN MJ, 1978, IMMUNOL REV, V42, P3, DOI 10.1111/j.1600-065X.1978.tb00256.x
[5] RECOGNITION OF A SELF MAJOR HISTOCOMPATIBILITY COMPLEX TL REGION PRODUCT BY GAMMA-DELTA T-CELL RECEPTORS
BONNEVILLE, M
ITO, K
KRECKO, EG
ITOHARA, S
KAPPES, D
ISHIDA, I
KANAGAWA, O
JANEWAY, CA
MURPHY, DB
TONEGAWA, S
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (15) : 5928 - 5932
[6] AUTOCRINE INDUCTION OF COLLAGENASE BY SERUM AMYLOID A-LIKE AND BETA-2-MICROGLOBULIN LIKE PROTEINS
BRINCKERHOFF, CE
MITCHELL, TI
KARMILOWICZ, MJ
KLUVEBECKERMAN, B
BENSON, MD
[J]. SCIENCE, 1989, 243 (4891) : 655 - 657
[7] H-2-RESTRICTION OF CONTACT INHIBITION OF EPITHELIAL-CELLS
CURTIS, ASG
ROONEY, P
[J]. NATURE, 1979, 281 (5728) : 222 - 223
[8] STRUCTURE AND EXPRESSION OF THE MOUSE BETA-2-MICROGLOBULIN GENE ISOLATED FROM SOMATIC AND NON-EXPRESSING TERATOCARCINOMA CELLS
DANIEL, F
MORELLO, D
LEBAIL, O
CHAMBON, P
CAYRE, Y
KOURILSKY, P
[J]. EMBO JOURNAL, 1983, 2 (07) : 1061 - 1065
[9] THYMOTAXIN, A CHEMOTACTIC PROTEIN, IS IDENTICAL TO BETA-2-MICROGLOBULIN
DARGEMONT, C
DUNON, D
DEUGNIER, MA
DENOYELLE, M
GIRAULT, JM
LEDERER, F
LE, KHD
GODEAU, F
THIERY, JP
IMHOF, BA
[J]. SCIENCE, 1989, 246 (4931) : 803 - 806
[10] INTRATHYMIC MATURATION OF MURINE LYMPHOCYTES-T FROM CD8+ PRECURSORS
GUIDOS, CJ
WEISSMAN, IL
ADKINS, B
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (19) : 7542 - 7546

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