BIOSYNTHESIS OF FUNGAL METABOLITES .10. STRUCTURES AND BIOSYNTHESIS OF MULTICOLANIC, MULTICOLIC, AND MULTICOLOSIC ACIDS, NOVEL TETRONIC ACID METABOLITES OF PENICILLIUM MULTICOLOR

被引：21

作者：

GUDGEON, JA ^{[1
]}

HOLKER, JSE ^{[1
]}

SIMPSON, TJ ^{[1
]}

YOUNG, K ^{[1
]}

机构：

[1] UNIV LIVERPOOL,ROBERT ROBINSON LABS,LIVERPOOL L69 3BX,MERSEYSIDE,ENGLAND

来源：

BIOORGANIC CHEMISTRY | 1979年 / 8卷 / 03期

关键词：

D O I：

10.1016/0045-2068(79)90058-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Multicolanic, multicolic, and multicolosic acids, metabolites of Penicillium multicolor, are shown by chemical transformations and spectroscopic methods to be 4-ylidenetetronic acids with structures (I), (II), and (III), respectively. The biosynthesis of these metabolites from acetate, via oxidative fission of preformed 6-pentylresorcylic acid is established by incorporation studies with [1-13C]-, [2-13C]-, [1,2-13C]acetate and ethyl [2-14C]-6-pentylresorcylate. © 1979.

引用

页码：311 / 322

页数：12

共 17 条

[1] A NEW SYNTHESIS OF OLIVETOL
ANKER, RM
COOK, AH
[J]. JOURNAL OF THE CHEMICAL SOCIETY, 1945, (MAY): : 311 - 313
[2] ENZYMIC FORMATION OF PENICILLIC ACID
AXBERG, K
GATENBECK, S
[J]. FEBS LETTERS, 1975, 54 (01) : 18 - 20
[3] INTERMEDIATES IN PENICILLIC ACID BIOSYNTHESIS IN PENICILLIUM-CYCLOPIUM
AXBERG, K
GATENBECK, S
[J]. ACTA CHEMICA SCANDINAVICA SERIES B-ORGANIC CHEMISTRY AND BIOCHEMISTRY, 1975, 29 (07): : 749 - 751
[4] TOTAL SYNTHESIS AND STEREOSTRUCTURE OF METHYL (E)-O-METHYLMULTICOLANATE, A 4-YLIDENETETRONIC ACID FROM PENICILLIUM-MULTICOLOR
BEGLEY, MJ
GEDGE, DR
PATTENDEN, G
[J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1978, (02) : 60 - 61
[5] BELCHER R, 1954, SEMIMICRO QUANTITATI, P160
[6] BIOSYNTHESIS OF FUNGAL XANTHONE RAVENELIN
BIRCH, AJ
BALDAS, J
HLUBUCEK, JR
SIMPSON, TJ
WESTERMAN, PW
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1976, (08): : 898 - 904
[7] STUDIES IN BIOCHEMISTRY OF MICRO-ORGANISMS .113. PENCOLIDE, A NITROGEN-CONTAINING METABOLITE OF PENCILLIUM MULTICOLOR GRIGORIEVAMANILOVA AND PORADIELOVA
BIRKINSHAW, JH
KALYANPUR, MG
STICKINGS, CE
[J]. BIOCHEMICAL JOURNAL, 1963, 86 (02) : 237 - &
[8] FELL SCM, 1979, J CHEM SOC CHEM COMM, V81
[9] USE OF SINGLY AND DOUBLY LABELED ACETATE-C-13 IN ELUCIDATION OF STRUCTURES AND BIOSYNTHESIS OF MULTICOLIC AND MULTICOLOSIC ACIDS, NEW TETRONIC ACIDS FROM PENICILLIUM-MULTICOLOR
GUDGEON, JA
HOLKER, JSE
SIMPSON, TJ
[J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1974, (16) : 636 - 638
[10] TETRONIC ACIDS
HAYNES, LJ
PLIMMER, JR
[J]. QUARTERLY REVIEWS, 1960, 14 (03): : 292 - 315

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