CALCITONIN GENE-RELATED PEPTIDE IN HUMAN OBESITY

被引：88

作者：

ZELISSEN, PMJ ^{[1
]}

KOPPESCHAAR, HPF ^{[1
]}

LIPS, CJM ^{[1
]}

HACKENG, WHL ^{[1
]}

机构：

[1] IJSSELLAND HOSP,DEPT ENDOCRINOL CHEM,ROTTERDAM,NETHERLANDS

来源：

PEPTIDES | 1991年 / 12卷 / 04期

关键词：

CALCITONIN GENE-RELATED PEPTIDE (CGRP); CALCITONIN; OBESITY (HUMAN); FEEDING BEHAVIOR;

D O I：

10.1016/0196-9781(91)90147-H

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We studied plasma calcitonin gene-related peptide (CGRP) levels in obese women before (n = 24) and after (n = 13) weight loss, and in normal weight controls (n = 15). Furthermore, the influence of two isocaloric meals (high carbohydrate vs. high fat) on plasma CGRP concentrations was studied. The CGRP concentration in the obese group (32.26 +/- 2.01 pg/ml) was significantly (p < 0.0001) higher than in the control group (21.64 +/- 0.015 pg/ml). After weight loss (14.3 +/- 0.72% of original weight) CGRP concentrations remained unchanged. Only the high-fat meal caused a significant (p < 0.02) rise in CGRP levels. Our results indicate that elevated plasma CGRP levels may constitute a primary phenomenon in obese women, and that fat intake may be associated with increased CGRP secretion.

引用

页码：861 / 863

页数：3

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