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DESIGN OF ENZYME-INHIBITORS USING ITERATIVE PROTEIN CRYSTALLOGRAPHIC ANALYSIS

被引：210
作者：
APPELT, K
BACQUET, RJ
BARTLETT, CA
BOOTH, CLJ
FREER, ST
FUHRY, MAM
GEHRING, MR
HERRMANN, SM
HOWLAND, EF
JANSON, CA
JONES, TR
KAN, CC
KATHARDEKAR, V
LEWIS, KK
MARZONI, GP
MATTHEWS, DA
MOHR, C
MOOMAW, EW
MORSE, CA
OATLEY, SJ
OGDEN, RC
REDDY, MR
REICH, SH
SCHOETTLIN, WS
SMITH, WW
VARNEY, MD
VILLAFRANCA, JE
WARD, RW
WEBBER, S
WEBBER, SE
WELSH, KM
WHITE, J
机构：
[1] Agouron Pharmaceuticals, Inc., La Jolla, California 92037
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 1991年 / 34卷 / 07期
关键词：
DIHYDROFOLATE-REDUCTASE INHIBITORS; RATIONAL DRUG DESIGN; THYMIDYLATE SYNTHASE; HUMAN-HEMOGLOBIN; QUINAZOLINE INHIBITOR; ACID CB3717; BINDING; SYNTHETASE; ANTIFOLATE; CELLS;
D O I：
10.1021/jm00111a001
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
[No abstract available]
引用
收藏
页码：1925 / 1934
页数：10
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