SCOPARIC ACID-A, A BETA-GLUCURONIDASE INHIBITOR FROM SCOPARIA-DULCIS

被引：33

作者：

HAYASHI, T

KAWASAKI, M

OKAMURA, K

TAMADA, Y

MORITA, N

TEZUKA, Y

KIKUCHI, T

MIWA, Y

TAGA, T

机构：

[1] TOYAMA MED & PHARMACEUT UNIV,RES INST WAKANYAKU ORIENTAL MED,TOYAMA,TOYAMA 93001,JAPAN

[2] KYOTO UNIV,FAC PHARMACEUT SCI,BUNKYO KU,KYOTO 606,JAPAN

来源：

JOURNAL OF NATURAL PRODUCTS | 1992年 / 55卷 / 12期

关键词：

D O I：

10.1021/np50090a005

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The 70% EtOH extract of Scoparia dulcis showed inhibitory activity against beta-glucuronidase from bovine liver. Bioassay-directed fractionation of the active extract led to the isolation of three labdane-type diterpene acids, scoparic acid A {1} [6-benzoyl-12-hydroxy-labda-8(17), 13-dien-18-oic acid], scoparic acid B [2] [6-benzoyl-14,15-dinor-13-oxo-8(17)-labden-18-oic acid], and scoparic acid C [3] [6-benzoyl-15-nor-14-oxo-8(17)-labden-18-oic acid], the structures of which were established by spectral means, including X-ray analysis. Scoparic acid A was found to be a potent beta-glucuronidase inhibitor.

引用

页码：1748 / 1755

页数：8

共 8 条

[1]

Chow S.Y., 1974, J FORMOSAN MED ASS, V73, P729

[2]

KAWASAKI M, 1987, CHEM PHARM BULL, V35, P3963

[3] THE PREPARATION AND PROPERTIES OF BETA-GLUCURONIDASE .4. INHIBITION BY SUGAR ACIDS AND THEIR LACTONES [J].

LEVVY, GA .

BIOCHEMICAL JOURNAL, 1952, 52 (04) :464-472

[4]

NOBUNAGA T, 1961, FUKUOKA ACTA MED, V52, P300

[5]

PINEDA EP, 1959, GASTROENTEROLOGY, V36, P202

[6]

SATYANARAYANA K, 1969, J INDIAN CHEM SOC, V46, P765

[7]

TAKADA H, 1982, CANCER RES, V42, P331

[8]

TORRES DMG, 1986, CATALOGO PLANTAS MED, P394

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