INTRACOLONIC BIOAVAILABILITY OF HUMAN CALCITONIN IN MAN

被引：20

作者：

BEGLINGER, C

BORN, W

MUFF, R

DREWE, J

DREYFUSS, JL

BOCK, A

MACKAY, M

FISCHER, JA

机构：

[1] UNIV ZURICH,DEPT ORTHOPAED SURG,CALCIUM METAB RES LAB,CH-8006 ZURICH,SWITZERLAND

[2] CIBA GEIGY PHARMACEUT CORP,DRUG PREFORMULAT & DELIVERY,HORSHAM,ENGLAND

[3] UNIV ZURICH,DEPT INTERNAL MED,CH-8006 ZURICH,SWITZERLAND

[4] UNIV HOSP BASEL,DEPT RES,DIV GASTROENTEROL,CH-4031 BASEL,SWITZERLAND

来源：

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY | 1992年 / 43卷 / 05期

关键词：

CALCITONIN; COLONIC ADMINISTRATION; BIOAVAILABILITY; PHARMACOKINETICS; PHARMACODYNAMICS; ADVERSE EFFECTS;

D O I：

10.1007/BF02285096

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Human calcitonin (hCT) injected into the lumen of the descending colon of normal human subjects was absorbed within minutes and could be recognized intact in plasma as shown by RIA in combination with reverse-phase HPLC. The absorption was low and variable, with bioavailabilities ranging from 0.01 % to 2.7 % relative to intravenously administered hCT (area under the concentration-time curve). With intravenous hCT serum calcium was lowered and the fractional urinary excretion of calcium, phosphorus, sodium and chloride was significantly stimulated. With the intracolonic hCT, the fractional urinary excretions of calcium, sodium and chloride were also marginally stimulated relative to intracolonic vehicle (placebo). In conclusion, hCT is absorbed intact from the colon, but the bioavailability is low and highly variable.

引用

页码：527 / 531

页数：5

共 23 条

[1] RELEASE OF GONADOTROPINS BY ORAL ADMINISTRATION OF SYNTHETIC LRF OR A TRIPEPTIDE FRAGMENT OF LRF [J].